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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

The SPLENDID matched cohort study included 5,053 adult patients with obesity who underwent bariatric surgery at Cleveland Clinic hospitals in Florida and Ohio and 25,265 patients who received usual care without surgery

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Importantly, C3G exhibited metal-coordination bonds with the binuclear copper active site via oxygen atoms of the ( m )meta-diphenols (A-ring) while EC and CH exhibited similar interactions with the mh-Tyr via oxygen atom on the ( o )ortho-diphenols or catechol group (B-ring) (Table S1, Fig